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Pre-Solicitation Notice – Notice of Intent to award on a Single Source Basis Title: Notice of Intent to Award a Single Source Purchase Order for the Renewal of One (1) Floating License for a computational Partek Flow Software Package for Large Scale Statistical Analysis and Data Mining – base year with 2 options. Notice Number: NOI_PCA-NIAMS-06946 Agency: Department of Health and Human Services, National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Contracting Office: HHS – Office of Mission Acquisition Solutions Product Service Code (PSC): OC code 6632 / PCS Code 10 (Analysis Instruments, Medical Laboratory Use) NAICS Code: 513210 (Software Publishers) Place of Performance: NIH/NIAMS, 9000 Rockville Pike, Bldg 50, Bethesda, MD 20892 Set Aside: Not Applicable (Single Source) Response Date: 05/26/2026 1:00 PM MST Description This is a Notice of Intent to negotiate on a sole source basis for a firm-fixed-price purchase order to Illumina, Inc. 5200 Illumina Way, San Diego, CA 92122-4616 NIH/NIAMS has a requirement for renewal of one (1) Floating License for a computational Partek Flow Software Package for Large Scale Statistical Analysis and Data Mining. The requirement being sought covers a base year plus two (2) subsequent option years. Base Year: 08/10/2026 – 08/09/2027 Option Year 1: 08/10/2027 – 08/09/2028 Option Year 2: 08/10/2028 – 08/09/2029 Requirement Details: Partek Flow is an advanced platform for large-scale genomics data analysis. Its Enterprise Edition supports a wide range of applications, including bulk RNA-seq, DNA-seq, ChIP-seq/ATAC-seq, microarray, and metagenomics. Add-on modules for single-cell and spatial data analysis are essential to meet the needs of multiple NIAMS Intramural Research Program (IRP) projects. Notably, recently developed tools for spatial single-cell RNA-seq analysis provide enhanced statistical and exploratory capabilities, significantly expanding the platform's single-cell omics functionality. These add-ons are a critical complement to the Enterprise Edition and provide substantial value to the Biodata Mining and Discovery Section (BDMS) and other NIAMS IRP researchers. Justification for Sole Source: Proprietary Technology: Partek Inc., now part of Illumina, is the sole developer and distributor of Partek Flow and its associated add-on tools, making it the only source for this software package. Licensing for the Partek Flow Toolkit includes ongoing feature enhancements and implementation of new functionalities throughout the license period. The platform offers advanced computational tools for analyzing complex genomics datasets, including CITE-seq, single-cell gene expression, ATAC-seq, and spatial transcriptomics. These capabilities are essential to the research conducted by BDMS (Biodata Mining and Discovery Section) within the NIAMS Intermural Research Program. Continuity of Service and Patient Data: BDMS initially acquired Partek Flow with…

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