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Special Notice – Notice of Intent to Sole Source SOLICITATION NUMBER: 75N98026Q00273 TITLE: Service/Maintenance Agreement renewal for the Discover 2.0 & Liberty Blue HT12/Razor microwave-assisted chemical synthesis systems made my CEM Corporation RESPONSE DATE: May 8, 2026, at 11:00 am EST. PRIMARY POINT OF CONTACT: Jaddua Johnston jaddua.johnston@mail.nih.gov Phone: 240-569-0006 INTRODUCTION: THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The purpose of this action is the renewal of a service agreement for the Discover 2.0 and Liberty Blue HT12/Razor bench‑top microwave reactors designed for small‑scale organic and medicinal chemistry synthesis used by the NCATS Early Translation Branch (ETB) Chemistry. This request is intended to begin a new coverage agreement including one preventative maintenance visit. Current PO for this service agreement is PO #: 75N95C24P00096 These instruments are being used for multiple projects in our chemistry lab, including but not limited to, TR000192-10 Selective Inhibitors of ALDH1A1; TR000436-04 Identification of ALPK1 inhibitors; TR000251-09 qHTS to Identify Inhibitors of NNMT1; TR000106-10 qHTS to Identify Inhibitors of DYT1 Inclusion Formation NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE and SET ASIDE STATUS NAICS code 811210 Electronic and Precision Equipment Repair and Maintenance @ $34 million. This acquisition is NOT set aside for small businesses. REGULATORY AUTHORITY This acquisition will be conducted using FAR Part 12 – Acquisition of Commercial Items in conjunction with FAR Part 13 – Simplified Acquisition Procedures, as applicable. The resultant contract will include all appropriate provisions and clauses in effect through the current Federal Acquisition Circular (FAC). STATUTORY AUTHORITY This acquisition is being conducted under the authority of: FAR 6.302-1 – Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements (41 U.S.C. 3304(a)(1)) DESCRIPTION OF REQUIREMENT: PURPOSE AND OBJECTIVES: We require a service/maintenance agreement for the Discover 2.0 and Liberty Blue HT12/Razor systems. The Liberty Blue system allows scientists to produce high-purity peptides, and the Discover 2.0 is a microwave reactor that aids in performing any organic or inorganic synthetic chemistry. Full function of this equipment is necessary for the continuity and standardization of NCATS research. The service agreement must include unlimited service visits (with troubleshooting and parts replacement coverage) preventative maintenance visits, original equipment manufacturer parts and accessories, and original equipment manufacturer (OEM) factory trained service engineers. These are specialized laboratory machines that help us make new drug ingredients faster, more consistently, and at lower development cost. Period of Performa…

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• Attachment 1