The Proactive Health Office (PHO) at ARPA-H is seeking solutions to improve the healthspan and health outcomes of Americans prior to the onset of disease and/or the development of diminished quality of life from illness. Specifically, PHO hypothesizes that 1) population-level improvements in access to and uptake of disease prevention and wellness-promoting behaviors and 2) development of novel early-detection methods and prophylactic interventions could drastically improve the health of American throughout their lives, and 3) that system level innovations are required for delivery of proactive health effectively. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 4 is effective immediately; however, if an entity has previously submitted a Solution Summary and a proposal, no action is required related to changes described in the amendment. If only a Solution Summary has been submitted; any future proposal must comply with this amendment. Amendment 04 includes the following changes: Updated Administrative and National Policy Requirements document (Note other Bundle of Attachment documents are unchanged) Minor changes throughout the ISO, including, but not limited to: Updating the name from ARPA-H Solution Submission Portal to ARPA-H Solutions Site , notation in paragraph 2.3, and revised language in Section 6.1 Research Security Disclosures to align with the updated Bundle of Attachments document.