The Center for Research on Genomics and Global Health (CRGGH) explores how genetic and environmental factors contribute to the onset of complex diseases like Type 2 diabetes, obesity, and hypertension. Over the past two decades, CRGGH has gathered phenotypic data from more than 6,000 individuals both in the United States and internationally. To better understand the underlying causes of metabolic disorders, CRGGH researchers utilize a variety of analytical methods. Over the years, they have systematically collected diverse types of -omics data, including genomics, transcriptomics, proteomics and microbiomes—from all or some participants, aiming to conduct integrated analyses that unravel underpinning mechanisms of these diseases.