This is a combined synopsis/solicitation for a commercial product/service prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a separate written solicitation will not be issued. This solicitation number is 75N98026Q00470 and is issued as a Request for Quote (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular (FAC) 2025-06 October 1, 2025. The North American Industrial Classification (NAICS) code 541511 with a size standard $134. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part Subpart 13.5. The purpose of this requirement is to maintain uninterrupted access to a mature, validated software platform that directly supports NCATS research objectives in translational science and preclinical therapeutic development. The software contributes to the NCATS mission by helping investigators more efficiently identify promising chemical matter, evaluate biological relevance, and advance discovery efforts toward potential interventions for human diseases and conditions. COMMITMENT OF PUBLIC FUNDS The Contracting Officer is the only individual who can legally commit the Government to the expenditure of public funds in connection with the proposed acquisition. Any other commitment, either explicit or implied, is invalid. COMMUNICATIONS PRIOR TO AWARD Offerors shall direct all communications to the attention of: Damian Hurge, Contracting Officer Email: Damian.Hurge@hhs.gov Communications with other officials may compromise the competitiveness of this acquisition and result in cancellation of the requirement. PREPARATION COSTS This RFQ does not commit the Government to pay for the preparation and submission of a quote. SUBMISSION REQUIREMENTS AND PROPOSAL DUE DATE : In order to receive an award, contractor must be registered and have a valid certification in Beta SAM (System for Award Management) https://beta.sam.gov/. Interested vendors capable of providing the Government with the services specified in this combined synopsis/solicitation shall submit electronic responses to Damian.Hurge@hhs.gov. Please reference solicitation 75N98026Q00470 on all correspondence to this notice. Quotes must be submitted electronically no later than Monday, June 15, 2026 at 2:30 PM EST. Period of Performance : 09/26/2026 – 09/25/2027 Transmittal Information : Include the following information in your proposal: DUNS number and TIN; Company Name mailing address, and website address; Company Point of Contact, Phone and Email address. Date submitted and proposal expiration date; All of the above-cited information for each entity on the proposed team, if a team is proposed; Do you have a Government approved accounting system? If so, please identify the agency that approved the system; Type of Company…