Sole Source - Production of ChAdOx-1 and MVA expressing mouse gp70view on SAM.gov

Title: Production of ChAdOx-1 and MVA expressing mouse gp70 Document type: Combined Synopsis/Intent to Sole Source Solicitation Number: RFQ# 75N98026Q00996 Proposed Post Date: 08/12/2026 Proposed Response Date: 08/19/2026 NAICS Code: 541714 Small Business Size Standard: 1,000 Contracting Office Address: Department of Health and Human Services, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20817 USA. Description: The National Cancer Center's (NCI) Laboratory of Integrative Cancer Immunology Branch / The Immune Regulation and Vaccine Development Section intends to award a sole-source purchase order using the procedures at FAR 13.106-1(b)(1), as it has been deemed that only one source is available to meet this specific requirement to provide service of producing chimpanzee adenovirus (ChAdOx-1) vectors and MVA viral vector expressing mouse gp70. This purchase order is intended to be awarded to Viral Vector Core at the Pandemic Institute, University of Oxford, Pandemic Science Institute - University of Oxford Old Road Campus Research Building (ORCRB), Oxford, OX3 7DQ, Oxford, OX3 7DQ. The requirements document in the form of a Statement of Work is attached to this notice. The acquisition will be processed in accordance with Sole Source Selection procedures as stated in FAR Part 6.302-1 and 41 U.S.C. 3304(a)(1and is exempt from the requirements of FAR Part 6. The North American Industry Classification System code is 541714 “Research and Development in Biotechnology (except Nanobiotechnology)” and the business size standard is 1,000 employees. In the development of a vaccine for glioblastoma, a high-grade brain tumor, there has been use of a combination of ChAdOx and MVA in syngeneic orthotopic mouse glioblastoma models. This has demonstrated this combination significantly prolongs the survival of tumor-bearing animals by inducing a robust population of tumor-specific CD8 T cells in the brain. The selection of this set of viral vectors, particularly the chimpanzee adenovirus ChAdOx-1, is to overcome the issue of pre-existing immunity to human adenoviruses. As the goal of this project is to evaluate the vaccine's efficacy in protecting against breast cancer brain metastasis, it is essential to use the same viral vector platform, the vendor currently providing chimpanzee adenovirus-based vectors. The Contractor shall provide/perform the following, unless otherwise noted: TECHNICAL REQUIREMENTS: Design and construction of a codon-optimized gene expression cassette encoding mouse gp70 and the mouse class II major histocompatibility complex invariant chain (Ii) for expression in mouse cells. Production of a ChAdOx-1 viral vector encoding the gene construct. Production of an MVA viral vector encoding the same gene construct. Viral Vector Core at the Pandemic Institute, University of Oxford is the only known vendor currently provide chimpanzee adenovirus-based vectors as this is the proprietary technology owned by the Viral Vector Core…