THIS IS A COMBINED SOURCES SOUGHT NOTICE AND NOTICE OF INTENT TO SOLE SOURCE*** The National Institute of Standards and Technology (NIST) is seeking information from sources that may be capable of providing a Microscale Thermophoresis Instrument. If no alternate sources are identified, the Government intends to issue a Sole Source Award to NanoTemper Technologies Inc., 400 OYSTER POINT BLVD, STE 336, SOUTH SAN FRANCISCO, CA 94080 , under the authority of FAR 13.106-1(b). The North American Industry Classification System (NAICS) code for this acquisition is 334516, Analytical Laboratory Instrument Manufacturing with a size standard of 1,000 Employees. The Biomolecular Structure and Function (BSF) Group requires a Microscale Thermophoresis (MST) instrument to support measurement science for biomanufacturing and formulated biotherapeutics. The requirement is for a solution-phase, non-flow, temperature-gradient-driven (thermophoretic) measurement platform capable of characterizing molecular transport and structural changes in both purified systems and complex solution environments. For a unified measurement framework, the instrument must provide both intrinsic fluorescence (label-free) and fluorescently labeled detection capabilities within a single integrated MST platform, allowing direct comparison of measurements while maintaining a consistent analytical methodology. NIST has a need for a Microscale Thermophoresis Instrument to support measurement science for biomanufacturing and formulated biotherapeutics. The requirement is for a solution-phase, non-flow, temperature-gradient-driven (thermophoretic) measurement platform capable of characterizing molecular transport and structural changes in both purified systems and complex solution environments. For a unified measurement framework, the instrument must provide both intrinsic fluorescence (label-free) and fluorescently labeled detection capabilities within a single integrated MST platform, allowing direct comparison of measurements while maintaining a consistent analytical methodology. The thermophoretic measurement platform capable of evaluating molecular transport behavior through temperature-gradient-driven migration. The static solution environment provided by MST is essential for direct comparison with NMR-derived measurements in the BSF group and for developing transferable biomanufacturing measurement methodologies. The use of separate instruments or multiple platforms would not satisfy the requirement. NIST specifically requires both intrinsic fluorescence (label-free) and fluorescently labeled measurements within a single MST platform to ensure cross-comparable measurements and consistent interpretation across purified samples, formulation matrices, and complex solution environments. The thermophoretic response depends strongly on the coupled optical and thermal characteristics of the instrument. Using separate instruments for intrinsic and labeled measurements would introduce pl…