The mission of the DARPA DSO is to identify, investigate, and leverage nascent scientific advances for national security applications by pursuing high-risk, high-payoff research initiatives across a broad spectrum of science and engineering disciplines. Disruption Opportunity (DO) topics are issued to rapidly investigate new concepts with focused investments. DOs enable DARPA to initiate a new investment for unclassified efforts in less than 120 calendar days from idea inception. To enable this approach, DSO will issue individual DOs under this solicitation. These opportunities will target specific technical domains important to DSO’s mission to pursue innovative research that leads to a prototype demonstration. More information about DSO’s technical domains and research topics of interest may be found at https://www.darpa.mil/about/offices/dso.