We purchased the GeoMx Digital Spatial Profiler (DSP) instrument to study tissue heterogeneity and the complexity of microenvironments in the spatial context related to alcohol-induced organ injury and in various fibrosis models. GeoMx DSP is the only spatial biology platform that non-destructively profiles the expression of RNA and protein from distinct tissue compartments and cell populations with an automated and scalable workflow that integrates with standard histology staining. This technique will help us discover novel biomarkers for disease severity, understand disease mechanisms and progression, uncover drug mechanisms of action, and study preclinical models. Currently, multiple labs at NIAAA plan to use this instrument for their ongoing projects.