The California Institute of Technology's (Caltech's) Jet Propulsion Laboratory (JPL), located at 4800 Oak Grove Drive, Pasadena, CA 91109, is issuing the subject RFI to obtain information from spacecraft operators, mission planners, and system integrators regarding camera requirements for space missions. This information will inform the development of flexible, modular spacecraft camera architectures and support subsequent vendor engagement. This RFI is to also gather information of potential qualified sources and to obtain your business size relative to the following NAICS code: 334511 - Search, Detection, Navigation, Guidance, Aeronautical, and Nautical System and Instrument Manufacturing with a size standard of 1,350 employees. Responses to this RFI may be used by JPL to make appropriate decisions regarding a Small Business Set-Aside procurement. Purpose NASA's shift toward sustained infrastructure operations with standardized, reusable platforms at continuous cadence, exemplified by initiatives supporting permanent lunar bases, commercial transportation systems, and "Science as a Service" missions, drives the need for adaptable, high-performance imaging systems. This transition from custom, mission-specific camera designs to flexible, modular camera platforms that can serve multiple applications aims to reduce development cost and risk, leverage commercial-off-the-shelf (COTS) ecosystems, and enable interoperability across diverse spacecraft systems. The purpose of this RFI is to assess spacecraft camera requirements across a wide range of mission applications including science imaging, autonomous navigation, proximity operations and docking, stellar navigation, engineering monitoring, and other uses to inform the design of a flexible camera architecture. The insights gathered will guide camera architecture definition and may lead to an RFP soliciting camera development or procurement from qualified vendors. The focus of this RFI is on the Command and Data Handling (C&DH) aspects of the camera - interfaces, protocols, storage, etc. with the goal of having a standardized camera interface, such that mission customization of camera optics does not require a re-design of the Avionics. Overview The flexible spacecraft camera capability is part of a broader NASA effort to modernize spacecraft avionics through reusable, standards-based components. By developing camera platforms that embrace open standards and interoperability, NASA aims to: Leverage commercial ecosystems: Benefit from ongoing advances in COTS imaging technologies, sensors, and processing capabilities Facilitate interoperability with COTS processing solutions: Emphasize open standards and compatibility with commercial image/video processing software Reduce development risk and cost: Build reusable camera platforms that can be adapted across multiple missions rather than developing one-off solutions, as well as providing a direct path from prototyping with COTS cameras to flight This…