The Defense Advanced Research Projects Agency (DARPA) Multi X Office (MXO) seeks information on low resource computing (LRC) paradigms and processes applicable to, but not yet utilized in, microsystems. DARPA is interested in identifying untapped potential for LRC within its operational and technological base. The Department of War (DoW) typically operates in environments with limited power, communication, or physical space, where mission completion depends on the ability to sustain critical computation and adapt at the edge. LRC offers a promising path towards advancing the DoW’s mission. DARPA is interested in disruptive concepts at the material, component, runtime, and authoring levels that represent significant advances beyond current practice for fielding robust, ultra-efficient systems.