The Medical Technology Enterprise Consortium (MTEC) is excited to post this pre-announcement for a Request for Project Proposals (RPP) in support of the Department of the Air Force. This effort focuses on the development of an autonomous closed loop control (ACLC) mechanical ventilator (MV). This device is expected to use advanced algorithms to automatically adjust ventilation settings for closed loop Positive End Expiratory Pressure (PEEP) based on the patient's physiological responses, minimizing the need for manual intervention. The goal is to create a lightweight, durable, and power-efficient ventilator that enhances patient safety and frees up medical personnel for other critical tasks during aeromedical evacuation and prolonged field care scenarios. ____________________________________________________________________________________ Background : The Department of the Air Force requires a next-generation mechanical ventilator to support casualties in austere, resource-limited, and prolonged-care environments. Current ventilators require frequent, manual adjustments by highly trained medical personnel, a demand that is unsustainable during en-route care or when managing multiple patients. The purpose of this effort is to reduce the technical risk associated with the ACLC/MV system by focusing on the design, development, and demonstration of the core Physiological Closed-Loop Control (PCLC) algorithms and the definition of the system's hardware architecture. A PCLC algorithm is essentially a “smart autopilot” for patient care, continuously adjusting treatment based on real-time physiology to keep patients stable. This one-year project will demonstrate the feasibility of the autonomous control concept and mature the system design to a level sufficient to support activities related to milestone B (Engineering & Manufacturing Development (EMD)). Technical Objective : This upcoming RPP focuses on the research, design, development, and testing of a ACLC/MV over a 12-month period. Proposed solutions should focus on both of the following: PCLC Algorithm: Develop and demonstrate a PCLC software algorithm capable of receiving physiological inputs and making autonomous adjustments to ventilator settings. System Architecture and Hardware Definition: Define the hardware architecture, including the assessment of candidate components and interfaces necessary to meet the environmental and performance requirements of military operations. This effort will result in a system demonstration(s) and review(s), providing the Government with the technical data needed to validate the proposed solution, culminating in a Go/No-Go decision point for follow-on funding. Additional details on the technical requirements and objectives are expected to be provided in the upcoming RPP. Potential Funding Availability and Period of Performance : The USG expects to make one award to a qualified Offeror for a period of performance not to exceed 12 months. Acquisition Approach : Thi…